Association between blood pressure and arterial compliance and G protein beta 3 subunit gene (GNB3) polymorphism (C825T)
نویسندگان
چکیده
منابع مشابه
The human G protein beta 3 subunit GNB3 825T polymorphism.
Meirhaeghe et al. recently showed that the T allele of a C vs T exchange at position 825 of the gene encoding for the beta3 subunit of heterotrimeric G proteins (GNB3) is associated with enhanced coronary constriction after intracoronary administration of methylergonovine. The 825T allele has also been shown to be associated with an enhanced response after activation of G protein coupled recept...
متن کاملAssociation of G-protein beta-3 subunit gene (GNB3) T825 allele with Type II diabetes.
To date, the human G-protein beta 3 subunit (GNB3) gene and some of its variants represent some of the best examples of genetic influences that are involved in the determination of hypertension and obesity, which make it a sensible candidate gene for type 2 diabetes. To assess the influence of GNB3 in type II diabetes mellitus (NIDDM), we carried out a retrospective, case-control study of varia...
متن کاملAssociation between a polymorphism in the G protein beta3 subunit gene and lower renin and elevated diastolic blood pressure levels.
Gi proteins mediate the intracellular effects of many vasoactive and proliferative stimuli. Recently such signaling was found to be enhanced in cultured cells of some hypertensive subjects. A polymorphism at position 825 (C-->T) of the G protein beta3 subunit gene (GNB3) was strictly related to this phenotype. The aim of the present investigation was to test the association between this polymor...
متن کاملAssociation Between a Polymorphism in the G Protein b3 Subunit Gene and Lower Renin and Elevated Diastolic Blood Pressure Levels
Gi proteins mediate the intracellular effects of many vasoactive and proliferative stimuli. Recently such signaling was found to be enhanced in cultured cells of some hypertensive subjects. A polymorphism at position 825 (C3T) of the G protein b3 subunit gene (GNB3) was strictly related to this phenotype. The aim of the present investigation was to test the association between this polymorphism...
متن کاملThe Association between GNB3 Gene Polymorphism and Obesity: A Systematic Review and Meta-Analysis
The association between Guanine Nucleotide Binding protein β protein polypeptide 3(GNB3) C825T polymorphism and obesity has recently been reported. However, the findings remain inconclusive. The aim of this systematic review and meta-analysis was to detect the relationship between GNB3 C825T polymorphism and obesity. Materials and Methods: Six electronic databases including Embase, Medlin...
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 2003
ISSN: 0895-7061
DOI: 10.1016/s0895-7061(03)00283-8